Explain Pain 2nd Edition (RESOLVE Study) - page 70

Recap
• All pain experiences are a normal response to
what your brain thinks is a threat.
• The amount of pain you experience does not
necessarily relate to the amount of tissue
damage.
• The construction of the pain experience of the
brain relies onmany sensory cues.
• Phantom limb pain serves as a reminder of
the virtual limb in the brain.
Recap
• Danger sensors are scattered all over the body.
• When the excitement level within a neurone
reaches the critical level, amessage is sent
towards the spinal cord.
• When a dangermessage reaches the spinal
cord it causes release of excitatory chemicals
into the synapse.
• Sensors in the dangermessenger neurone are
activated by those excitatory chemicals and
when the excitement level of the danger
messenger neurone reaches the critical level,
a dangermessage is sent to the brain.
• Themessage is processed throughout the brain
and if the brain concludes you are indanger and
youneed to take action, itwill produce pain.
• The brain activates several systems that work
together to get you out of danger.
Recap
Tissue damage causes inflammation, which
directly activates danger sensors andmakes
neuronesmore sensitive.
Inflammation in the short term promotes
healing.
Tissue healing depends on the blood supply
and demands of the tissue involved, but all
tissues can heal.
The peripheral nerves themselves and the
dorsal root ganglion (DRG) can stimulate
danger receptors. Normally, pain initiated by
dangermessages from the nerves and DRG
follows a particular pattern.
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